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Masashi Okada Selected Research

3,9-bis((ethylthio)methyl)-K-252a

12/2023CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells.
8/2023Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells.
7/2023The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo.
10/2022CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells.
9/2020Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway.
8/2018A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel.
11/2017Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug.

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Masashi Okada Research Topics

Disease

46Neoplasms (Cancer)
04/2024 - 08/2003
18Glioblastoma (Glioblastoma Multiforme)
04/2024 - 01/2012
14Glioma (Gliomas)
04/2024 - 01/2012
10Ovarian Neoplasms (Ovarian Cancer)
06/2023 - 09/2014
10Pancreatic Neoplasms (Pancreatic Cancer)
12/2020 - 07/2014
5Meningioma (Meningiomas)
07/2023 - 10/2017
5Lung Neoplasms (Lung Cancer)
10/2019 - 12/2009
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2020 - 05/2016
3Parkinson Disease (Parkinson's Disease)
10/2022 - 11/2017
3Neoplasm Metastasis (Metastasis)
12/2018 - 10/2013
2Brain Neoplasms (Brain Tumor)
08/2023 - 07/2022
2Retinoblastoma (Glioblastoma, Retinal)
10/2022 - 09/2020
2Seizures (Absence Seizure)
07/2013 - 08/2012
2Ischemia
08/2012 - 04/2012
2Alopecia (Baldness)
08/2003 - 06/2003
1Uveal melanoma
12/2023
1Polycythemia Vera
03/2023
1Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
08/2020
1Hypertension (High Blood Pressure)
08/2020
1Macular Degeneration (Age-Related Maculopathy)
01/2020
1Schizophrenia (Dementia Praecox)
07/2019
1Breast Neoplasms (Breast Cancer)
09/2018
1Vomiting
11/2017
1Nausea
11/2017
1Mitochondrial Diseases (Mitochondrial Disease)
01/2017

Drug/Important Bio-Agent (IBA)

12SurvivinIBA
04/2024 - 12/2016
8GemcitabineFDA Link
03/2022 - 12/2016
73,9-bis((ethylthio)methyl)-K-252aIBA
12/2023 - 11/2017
6Proteins (Proteins, Gene)FDA Link
06/2023 - 02/2009
6Phosphotransferases (Kinase)IBA
10/2022 - 09/2013
5Paclitaxel (Taxol)FDA LinkGeneric
06/2023 - 01/2016
5osimertinibIBA
09/2021 - 07/2019
4Tyrosine Kinase InhibitorsIBA
09/2021 - 07/2019
4ErbB Receptors (EGF Receptor)IBA
09/2021 - 08/2018
4Antipsychotic Agents (Antipsychotics)IBA
09/2019 - 10/2016
4bentamapimodIBA
02/2019 - 05/2016
4Glucose (Dextrose)FDA LinkGeneric
08/2018 - 04/2012
3Cisplatin (Platino)FDA LinkGeneric
06/2023 - 01/2016
3JNK Mitogen-Activated Protein KinasesIBA
08/2022 - 09/2014
3Indicators and Reagents (Reagents)IBA
08/2021 - 03/2010
3Apoptosis Regulatory ProteinsIBA
12/2020 - 05/2019
3brexpiprazoleIBA
09/2019 - 05/2019
3Liposomes (Liposome)IBA
01/2014 - 12/2009
3Kainic Acid (Kainate)IBA
07/2013 - 10/2007
2Histone Deacetylase InhibitorsIBA
06/2023 - 03/2023
2domatinostatIBA
06/2023 - 07/2022
2Transcription Factors (Transcription Factor)IBA
06/2023 - 02/2015
2Messenger RNA (mRNA)IBA
06/2023 - 10/2022
2Temozolomide (Temodar)FDA LinkGeneric
03/2023 - 02/2014
2Therapeutic UsesIBA
03/2022 - 01/2011
2navitoclaxIBA
03/2022 - 01/2021
2DNA (Deoxyribonucleic Acid)IBA
10/2019 - 02/2014
2Serotonin (5 Hydroxytryptamine)IBA
07/2019 - 05/2019
2Dopamine (Intropin)FDA LinkGeneric
07/2019 - 05/2019
2Epidermal Growth Factor (EGF)IBA
07/2019 - 01/2014
2Aripiprazole (Abilify)FDA Link
05/2019 - 10/2016
2Coloring Agents (Dyes)IBA
09/2018 - 12/2016
2ResveratrolIBA
01/2015 - 07/2013
2Oxygen (Dioxygen)IBA
04/2012 - 12/2009
1Proto-Oncogene Proteins c-mdm2IBA
08/2023
1givinostatIBA
03/2023
1Histone Deacetylases (Histone Deacetylase)IBA
03/2023
1Phospholipases (Phospholipase)IBA
08/2022
1EverolimusFDA Link
03/2022
1Folic Acid (Vitamin M)FDA LinkGeneric
10/2021
1Lurasidone HydrochlorideFDA Link
09/2021
1Deoxycytidine KinaseIBA
01/2021
1Equilibrative Nucleoside Transporter 1IBA
01/2021
1SenotherapeuticsIBA
01/2021
1Dual Specificity Phosphatase 1IBA
12/2020
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
12/2020
1Dexamethasone (Maxidex)FDA LinkGeneric
12/2020
1QuinazolinesIBA
08/2020
1Doxazosin (Cardura)FDA LinkGeneric
08/2020
1Verteporfin (Visudyne)FDA Link
01/2020
1Spironolactone (Aldactone)FDA LinkGeneric
10/2019
1DiureticsIBA
10/2019
1PotassiumIBA
10/2019
1Carboplatin (JM8)FDA LinkGeneric
12/2018
1ConnexinsIBA
09/2018
1Gefitinib (Iressa)FDA Link
08/2018
1Erlotinib Hydrochloride (CP 358,774)FDA Link
08/2018
1AntiemeticsIBA
11/2017
1Fluorouracil (Carac)FDA LinkGeneric
11/2017
1Olanzapine (Zyprexa)FDA Link
11/2017
1AntimetabolitesIBA
10/2017
1Cytostatic AgentsIBA
10/2017
1licochalcone AIBA
01/2017
1Y 27632IBA
12/2016
1fasudil (AT 877)IBA
12/2016
1Protein Kinases (Protein Kinase)IBA
12/2016
1Antineoplastic Agents (Antineoplastics)IBA
11/2016
1ChromatinIBA
11/2016

Therapy/Procedure

18Therapeutics
04/2024 - 01/2012
5Drug Therapy (Chemotherapy)
07/2023 - 01/2016
2Adjuvant Radiotherapy
01/2021 - 01/2021
2Radiotherapy
10/2017 - 07/2013
2Chemoradiotherapy
01/2017 - 02/2014
2Injections
12/2009 - 08/2003
1Perforator Flap
09/2018